Hemolytic uremic syndrome and thrombotic thrombocytopenic purpura Masset C - Rev Med Liege - 01-JAN-2002; 57(1): 33-9 From NIH/NLM MEDLINE

ABSTRACT:

Hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are thrombotic microangiopathies (TMA). Both familial and sporadic forms exist: anaemia, thrombopaenia, renal failure and neurologic disorders are common clinical features. The differential diagnosis depends on plasma levels of von Willebrand factor-cleaving protease: there is a deficiency of this protease in patients with TTP whereas its rate is normal in HUS. We remind pathophysiology, etiologies and treatment of these TMA.