Information on Thrombotic Thrombocytopenic Purpura


Glossary of TTP Terms

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46. hematologic: related to the study of blood cells

47. hematuria: blood in the urine

48. hemiparesis: muscular weakness or partial paralysis restricted to one side of the body

49. hemoglobin: oxygen carrying protein of the red blood cells

50. hemolytic anemia: anemia caused by excessive destruction (as in chemical poisoning, infection, or sickle-cell anemia) of red blood cells

51. hemorrhagic colitis: bloody infection/inflammation of the colon (bowel)

52. hemostatic: an agent that checks bleeding; especially one that shortens the clotting time of blood

53. histological: in reference to the minute structure of tissues discernible with the microscope

54. hyperfiltration: abnormal increase in the filtration rate of the renal glomeruli

55. hyperperfusion: increased passage of a fluid through the vessels of a specific organ, like the kidney

56. hypertension: high blood pressure

57. hypochlorhydria: presence of an abnormally small amount of hydrochloric acid in the stomach.

58. hyponatremia: deficiency of sodium (salt) in the blood

59. idiopathic: self originated; of unknown causation; primary

60. IgG: a class of immunoglobulins that include the most common antibodies circulating in the blood, that facilitate the destruction of microorganisms foreign to the body, that bind to and activate complement, and that are the only immunoglobulins to cross over the placenta from mother to fetus

61. IgM: a class of immunoglobulins of high molecular weight that include the primary antibodies released into the blood early in the immune response to be replaced later by IgGs of lower molecular weight and that are highly efficient in binding complement

62. immunocompromised: having the immune system impaired or weakened (as by drugs or illness)

63. immunosuppressive: pertaining to a lessening of the body's immune response

64. infarct/infarction: an area of necrosis (death) in a tissue or organ resulting from obstruction of the local circulation by a thrombus or embolus

65. internal/external capsule: fibrous express ways that contain nerves to transmit information within certain parts of the brain

66. in vitro: outside the living body and in an artificial environment

67. intravenous (IV): within a vein

68. ischemia: localized tissue anemia due to obstruction of the inflow of arterial blood (as by the narrowing of arteries by spasm or disease)

69. jaundice: a yellowish pigmentation of the skin, tissues, and certain body fluids caused by the deposition of bile pigments that follows interference with normal production and discharge of bile (as in certain liver diseases) or excessive breakdown of red blood cells (as after internal hemorrhage or in various hemolytic states)

70. lactic dehydrogenase (LDH): The enzyme that catalyses the formation and removal of lactate; lactate is important as the terminal product of anaerobic glycolysis; accumulation of lactate in tissues is responsible for the so-called oxygen debt.

71. leukocyte: white blood cell

72. leukocytosis: increase in the number of white blood cells

73. lumen (plural: lumina): the cavity of a tubular organ

74. metalloprotease deficient: refers to a decrease in a specific blood factor that plays an important role in platelet adhesion, thrombus formation, and coagulation associated with TTP

75. microangiopathy: a disease of very fine blood vessels

76. microvascular/microvasculature: of, relating to, or constituting the part of the circulatory system made up of minute vessels (as venules or capillaries) that average less than 0.3 millimeters in diameter

77. monoclonal antibody: an antibody derived from a single cell in large quantities for use against a specific antigen

78. morbidity: the incidence of disease; the rate of sickness (as in a specified community or group)

79. morphologic: of, relating to, or concerned with form or structure

80. mortality: the number of deaths in a given time or place; the proportion of deaths in a given population

81. MRI/magnetic resonance imaging: a radiology technique using magnetism, radio waves, and a computer to produce images of body structures

82. multivariate analysis: a statistical procedure to determine the relationship of two or more factors, while taking into account other factors, in a set of study data

83. nephrectomy: removal of the kidney

84. nephron: The structural and functional unit of the kidney. It is made up of the glomerulus, Bowman's capsule and the convoluted tubule

85. nephrotic syndrome: a constellation of signs and symptoms including protein in the urine, low blood protein levels, high cholesterol levels, and swelling; results in damage to the kidneys, particularly the basement membrane of the glomerulus

86. neutrophil: type of white blood cell, filled with neutrally-staining granules, tiny sacs of enzymes that help the cell to kill and digest microorganisms it has engulfed

87. oliguria: reduced excretion of urine

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