Glossary of TTP Terms
[A-G] [H-O] [P-Z]
46. hematologic: related to the study of blood cells
47. hematuria: blood in the urine
48. hemiparesis: muscular weakness or partial paralysis restricted to one side of the body
49. hemoglobin: oxygen carrying protein of the red blood cells
50. hemolytic anemia: anemia caused by excessive destruction (as in chemical poisoning, infection, or sickle-cell anemia) of red blood cells
51. hemorrhagic colitis: bloody infection/inflammation of the colon (bowel)
52. hemostatic: an agent that checks bleeding; especially one that shortens the clotting time of blood
53. histological: in reference to the minute structure of tissues discernible with the microscope
54. hyperfiltration: abnormal increase in the filtration rate of the renal glomeruli
55. hyperperfusion: increased passage of a fluid through the vessels of a specific organ, like the kidney
56. hypertension: high blood pressure
57. hypochlorhydria: presence of an abnormally small amount of hydrochloric acid in the stomach.
58. hyponatremia: deficiency of sodium (salt) in the blood
59. idiopathic: self originated; of unknown causation; primary
60. IgG: a class of immunoglobulins that include the most common antibodies circulating in the blood, that facilitate the destruction of microorganisms foreign to the body, that bind to and activate complement, and that are the only immunoglobulins to cross over the placenta from mother to fetus
61. IgM: a class of immunoglobulins of high molecular weight that include the primary antibodies released into the blood early in the immune response to be replaced later by IgGs of lower molecular weight and that are highly efficient in binding complement
62. immunocompromised: having the immune system impaired or weakened (as by drugs or illness)
63. immunosuppressive: pertaining to a lessening of the body's immune response
64. infarct/infarction: an area of necrosis (death) in a tissue or organ resulting from obstruction of the local circulation by a thrombus or embolus
65. internal/external capsule: fibrous express ways that contain nerves to transmit information within certain parts of the brain
66. in vitro: outside the living body and in an artificial environment
67. intravenous (IV): within a vein
68. ischemia: localized tissue anemia due to obstruction of the inflow of arterial blood (as by the narrowing of arteries by spasm or disease)
69. jaundice: a yellowish pigmentation of the skin, tissues, and certain body fluids caused by the deposition of bile pigments that follows interference with normal production and discharge of bile (as in certain liver diseases) or excessive breakdown of red blood cells (as after internal hemorrhage or in various hemolytic states)
70. lactic dehydrogenase (LDH): The enzyme that catalyses the formation and removal of lactate; lactate is important as the terminal product of anaerobic glycolysis; accumulation of lactate in tissues is responsible for the so-called oxygen debt.
71. leukocyte: white blood cell
72. leukocytosis: increase in the number of white blood cells
73. lumen (plural: lumina): the cavity of a tubular organ
74. metalloprotease deficient: refers to a decrease in a specific blood factor that plays an important role in platelet adhesion, thrombus formation, and coagulation associated with TTP
75. microangiopathy: a disease of very fine blood vessels
76. microvascular/microvasculature: of, relating to, or constituting the part of the circulatory system made up of minute vessels (as venules or capillaries) that average less than 0.3 millimeters in diameter
77. monoclonal antibody: an antibody derived from a single cell in large quantities for use against a specific antigen
78. morbidity: the incidence of disease; the rate of sickness (as in a specified community or group)
79. morphologic: of, relating to, or concerned with form or structure
80. mortality: the number of deaths in a given time or place; the proportion of deaths in a given population
81. MRI/magnetic resonance imaging: a radiology technique using magnetism, radio waves, and a computer to produce images of body structures
82. multivariate analysis: a statistical procedure to determine the relationship of two or more factors, while taking into account other factors, in a set of study data
83. nephrectomy: removal of the kidney
84. nephron: The structural and functional unit of the kidney. It is made up of the glomerulus, Bowman's capsule and the convoluted tubule
85. nephrotic syndrome: a constellation of signs and symptoms including protein in the urine, low blood protein levels, high cholesterol levels, and swelling; results in damage to the kidneys, particularly the basement membrane of the glomerulus
86. neutrophil: type of white blood cell, filled with neutrally-staining granules, tiny sacs of enzymes that help the cell to kill and digest microorganisms it has engulfed
87. oliguria: reduced excretion of urine
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